Computational Epigenomics & Chromatin Biology
Methylation, chromatin accessibility and genome architecture — the strongest route to solving cancer of unknown primary.
What this centre does
Cancer is driven not only by changes in DNA sequence but by changes in how that DNA is packaged, marked and read. This centre studies the epigenome and chromatin architecture computationally, to understand epigenetic drivers and identify epigenetic biomarkers and targets.
Methods
Methylation analysis and classifier building; chromatin accessibility and 3D genome analysis; regulatory network inference; epigenetic age and signature analysis.
Data inputs
Methylation and accessibility assays via collaborators; public epigenomic atlases; matched clinical annotation.
Outputs
Methylation classifiers; epigenetic biomarker candidates; publications.
Funding route
Epigenomics and biomarker grant calls; academic collaboration.
What has to be true first
Collaborator access to methylation and accessibility assays.
Themes this centre carries
Work with this centre
The research centres collaborate with funders, sponsors, hospitals and academic groups. Tell us what you are working on and the enquiry is routed to the centre lead.
Contact the research office