KPCIRCKwatra Precision Cancer Institute and Research Centre
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Genetics & risk

Understand inherited risk. Make informed decisions.

Some cancer-risk questions relate to personal and family history and whether an inherited factor may be relevant. KPCIRC’s risk-assessment and genetic-counselling pathways help clarify the question, discuss the value and limits of testing, and consider suitable next steps.

Assessment first. Testing only where it helps.

Testing is not always the first or only step. Assessment and counselling help clarify what a test can and cannot answer.

  1. Personal and family history

    Understand the question and the history behind it.

  2. Counselling

    Discuss testing options, expected information, limitations and consequences.

  3. Test suitability

    Assess whether testing is appropriate and choose a route where indicated.

  4. Interpretation

    Review the result in the context of the clinical question and the report.

  5. Family and next steps

    Discuss what the result may mean for you and relevant relatives, including follow-up or referral.

What a risk assessment can cover

  • Personal cancer history and relevant diagnosis information.
  • Family history, including the types of cancer and ages at diagnosis where known.
  • Whether the pattern suggests that counselling or further evaluation is worth considering.
  • What a hereditary test may and may not be able to answer.
  • Possible implications of a result for you and family members.
  • Possible next steps: testing, a screening discussion, referral or no additional testing at that time.
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Genetics and risk services

Cancer risk assessment

A structured review of personal and family history to decide whether screening, counselling or further review may be appropriate.

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Genetic counselling

Pre-test and post-test discussion of why a test may or may not help, what results can mean and the implications for relatives.

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Heritage 65 and Heritage 160+

Core and extended hereditary-panel pathways, chosen to match the clinical question rather than the number of genes.

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PGx Safe Start

Pharmacogenomics: selected gene–medicine relationships, kept distinct from hereditary cancer risk.

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Questions people often ask

Does a hereditary panel tell me for certain whether I will get cancer?

No. Testing can identify certain inherited variants, but a result does not generally provide certainty about whether or when someone will develop cancer.

Should everyone with cancer have hereditary testing?

Testing decisions depend on clinical indications, personal and family history, tumour type, current guidance and the question being addressed. A clinical assessment is important.

What if a result is uncertain?

Some results do not clearly establish whether a variant is linked to disease risk. Uncertain findings are explained as uncertain and are not treated as established causes.

Will family members need testing?

That depends on the finding, its interpretation and the family context. Discuss implications with the qualified clinician or genetic counsellor responsible for the result.

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